From Interstate 5:
Driving either north or south on I-5, take I-8 east 2 miles, exit at Mission Center Road, turn right off the exit then make an immediate left onto Camino del Rio South (moving east) approximately 1/2 mile. The Scottish Rite Event Center will be on the right hand side.

From I-805:
Driving either north or south on 805, take I-8 west 1/4 mile to the Mission Center Road exit. At the light at the end of the exit, turn left and proceed to the next light (Mission Center Road / Auto Circle), turn left onto the bridge over the freeway. Go to the end of the bridge and turn left onto Camino del Rio South (moving east) approximately 1/2 mile. The Scottish Rite Event Center will be on the right hand side.

From 163:
Driving either north or south, take I-8 east and stay to the right, exit immediately at Mission Center Road. Turn right off the exit then make an immediate left onto Camino del Rio South (moving east) approximately 1/2 mile. The Scottish Rite Event Center will be on the right hand side.

From Interstate 15:
Driving south take the I-8 west/beaches & Camino del Rio South exit, take the split to Camino del Rio South. Turn right on Camino del Rio South at the light. Drive 2 miles (moving west) on Camino del Rio South. The Scottish Rite Event Center will be on the left hand side.

From Interstate 8:
Moving west from East County, drive into the Mission Valley area, exit at Texas Street. At the end of the exit, stay on Texas Street until just over the freeway bridge, turn right onto Camino del Rio south, proceed 1/4 mile. The Scottish Rite Event Center will be on the left hand side.